Surgical Pathology of Hepatobiliary Tumors by Wen-Ming Cong

Author:Wen-Ming Cong
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

However, no uniform criterion for the tumor volume of SHCC has been accepted at home and abroad, and 5 cm of SHCC in diameter is still in use by many scholars, which is not correspondent to the biological characteristics of early HCC or current clinical techniques in early detection and early diagnosis of HCC. The present international staging systems, such as BCLC and AASLD, defined the early HCC as tumors ≤3 cm and very early HCC as tumors ≤2 cm. Nevertheless, up to now, most studies on SHCC ≤2 cm are based on multicenter joint studies with long-term data collection, and among the cases of surgically resected HCC in centers for hepatic diseases all around the world, reports of SHCC ≤2 cm are still very rare with only a few studies on their biological characteristics (Table 7.3). For instance, Minagawa et al. (2007) collected 2767 cases of ≤2 cm SHCC from 829 units in Japan during a 30-year period. This is a summary of a huge sample, but the actual number of cases in each year for each unit is minimal. Farinati et al. (2009) analyzed the data of 1834 HCC cases (partly confirmed by pathology) during 10 years accumulated by the Cancer of the Liver Italian Program (ITA.​LI.​CA) and found that cases of ≤2 cm SHCC accounted for only 3%, which could not be analyzed for internal validation due to the insufficient number of cases. Thus, the authors suggested that the tumor volume of ≤2 cm as a criterion for the diagnosis of SHCC is of less staging significance in clinical practice because these cases are few in number.Table 7.3Researches on SHCC ≤2 cm in the literature

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